Spring Quarterly Meeting
Wednesday March 13th, 2024
Agios Pharmaceuticals, 88 Sidney St., Cambridge, MA 02139 USA
5:30 – 8:30 pm EST
Transport across the blood-brain barrier and subcutaneous delivery of ADCs: On the predictive power of in vitro models
Roger D. Kamm, PhD
Distinguished Professor of Biological and Mechanical Engineering
Recent interest in the delivery of therapeutics to the brain has dramatically increased with the advent of new antigen drug conjugates (ADC) and other targeted delivery modalities for the treatment of dementias and glioblastoma. In addition, subcutaneous delivery has been found to be an effective mode of ADC delivery, but the bioavailability in humans has been difficult to predict. These two factors have driven an increased interest in human cell-based in vitro models for screening novel delivery modalities and to gain mechanistic insight into the factors that control either entry into the brain or systemic bioavailability of subcutaneously delivered drugs. In this presentation I will present models specifically developed for both applications and the potential for iPS cell-derived systems. The benefits and current limitations of these models will also be addressed with the goal of stimulating an active discussion.